ADPRS (ADP-ribosylserine hydrolase)

2019-04-01  

Identity

HGNC
ADPRS
LOCATION
1p34.3
LOCUSID
54936
ALIAS
ADPRHL2,ARH3,CONDSIAS

Other Information

Locus ID:

NCBI: 54936
MIM: 610624
HGNC: 21304
Ensembl: ENSG00000116863

Variants:

dbSNP: 54936
ClinVar: 54936
TCGA: ENSG00000116863
COSMIC: ADPRS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116863ENST00000373178Q9NX46

References

Pubmed IDYearTitleCitations
383651962024Delineation of ADPRHL2 Variants: Report of Two New Patients with Review of the Literature.0
383651962024Delineation of ADPRHL2 Variants: Report of Two New Patients with Review of the Literature.0
338942022021Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions.1
340198112021Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.44
346255442021The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.39
338942022021Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions.1
340198112021Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.44
346255442021The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.39
326363692020Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair.17
327534842020AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair.6
326363692020Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair.17
327534842020AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair.6
308308642019PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.25
308308642019PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.25
294808022018Serine is the major residue for ADP-ribosylation upon DNA damage.128

Citation

Dessen P

ADPRS (ADP-ribosylserine hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57887/case-report-explorer/css/lib/humanGenome