AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1)

2014-11-01 Affiliation

Identity

HGNC

AGPAT1

LOCATION

6p21.32

LOCUSID

10554

ALIAS

1-AGPAT1,G15,LPAAT-alpha,LPAATA

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10554
MIM: 603099
HGNC: 324
Ensembl: ENSG00000204310

Variants:

dbSNP: 10554
ClinVar: 10554
TCGA: ENSG00000204310
COSMIC: AGPAT1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204310	ENST00000336984	Q99943
ENSG00000204310	ENST00000336984	A0A024RCV5
ENSG00000204310	ENST00000375104	Q99943
ENSG00000204310	ENST00000375104	A0A024RCV5
ENSG00000204310	ENST00000375107	Q99943
ENSG00000204310	ENST00000375107	A0A024RCV5
ENSG00000204310	ENST00000395496	Q99943
ENSG00000204310	ENST00000395496	A0A024RCV5
ENSG00000204310	ENST00000395497	Q99943
ENSG00000204310	ENST00000395497	A0A024RCV5
ENSG00000204310	ENST00000395499	Q99943
ENSG00000204310	ENST00000395499	A0A024RCV5

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerophospholipid metabolism	KEGG	ko00564
Glycerolipid metabolism	KEGG	hsa00561
Glycerophospholipid metabolism	KEGG	hsa00564
Metabolic pathways	KEGG	hsa01100
Fat digestion and absorption	KEGG	ko04975
Fat digestion and absorption	KEGG	hsa04975
Triacylglycerol biosynthesis	KEGG	hsa_M00089
Triacylglycerol biosynthesis	KEGG	M00089
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Triglyceride Biosynthesis	REACTOME	R-HSA-75109
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Integration of energy metabolism	REACTOME	R-HSA-163685
ChREBP activates metabolic gene expression	REACTOME	R-HSA-163765
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35363634	2022	AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis.	1
35363634	2022	AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis.	1
19143821	2009	Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.	6
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	58
19143821	2009	Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.	6
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	58
17707131	2007	Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1.	35
17707131	2007	Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1.	35
16571775	2006	Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages.	2
16571775	2006	Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages.	2

Citation

Dessen P

AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60203/css/lib/case-report-explorer/