AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1)

2014-11-01  

Identity

HGNC
AREL1
LOCATION
14q24.3
LOCUSID
9870
ALIAS
FIEL1,KIAA0317
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9870
MIM: 615380
HGNC: 20363
Ensembl: ENSG00000119682

Variants:

dbSNP: 9870
ClinVar: 9870
TCGA: ENSG00000119682
COSMIC: AREL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119682ENST00000356357O15033
ENSG00000119682ENST00000481010H0YJ69
ENSG00000119682ENST00000490805H0YJK5
ENSG00000119682ENST00000553279G3V5P7
ENSG00000119682ENST00000553411H0YJF1
ENSG00000119682ENST00000554070H0YJ67
ENSG00000119682ENST00000555249G3V245
ENSG00000119682ENST00000555330G3V2B5
ENSG00000119682ENST00000556202G3V506

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375223292023AREL1 resists the apoptosis induced by TGF-β by inhibiting SMAC in vascular endothelial cells.1
375223292023AREL1 resists the apoptosis induced by TGF-β by inhibiting SMAC in vascular endothelial cells.1
321512812020Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients.14
321512812020Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients.14
317325612019Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro.6
317325612019Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro.6
271621392016Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.22
271621392016Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.22
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60454/gene-fusions/teaching-explorer/