CHST1 (carbohydrate sulfotransferase 1)

2014-11-01 Affiliation

Identity

HGNC

CHST1

LOCATION

11p11.2

LOCUSID

8534

ALIAS

C6ST,GST-1,KS6ST,KSGal6ST,KSST

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8534
MIM: 603797
HGNC: 1969
Ensembl: ENSG00000175264

Variants:

dbSNP: 8534
ClinVar: 8534
TCGA: ENSG00000175264
COSMIC: CHST1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175264	ENST00000308064	O43916

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	ko00533
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	hsa00533
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10804	imatinib	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	30237583
PA151958383	Gastrointestinal Stromal Tumors	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	30237583
PA443937	Drug Toxicity	Disease	VariantAnnotation	associated	PD	30237583

References

Pubmed ID	Year	Title	Citations
21880669	2012	Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epitopes of KL-6(MUC1) monoclonal antibody.	21
22260995	2012	Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules.	5
21880669	2012	Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epitopes of KL-6(MUC1) monoclonal antibody.	21
22260995	2012	Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules.	5
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	58
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	58
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	4
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	4
18698629	2008	Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.	16
18698629	2008	Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.	16
17690104	2007	Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.	25
17690104	2007	Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.	25
16495484	2006	Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.	8
16495484	2006	Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.	8
15324304	2004	Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.	1

Citation

Dessen P

CHST1 (carbohydrate sulfotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61819/deep-insight-explorer/meetings/gene-fusions-explorer/