CHST1 (carbohydrate sulfotransferase 1)

2014-11-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
C6ST,GST-1,KS6ST,KSGal6ST,KSST
FUSION GENES

Other Information

Locus ID:

NCBI: 8534
MIM: 603797
HGNC: 1969
Ensembl: ENSG00000175264

Variants:

dbSNP: 8534
ClinVar: 8534
TCGA: ENSG00000175264
COSMIC: CHST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175264ENST00000308064O43916

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10804imatinibChemicalClinicalAnnotation, VariantAnnotationassociatedPD30237583
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD30237583
PA443937Drug ToxicityDiseaseVariantAnnotationassociatedPD30237583

References

Pubmed IDYearTitleCitations
218806692012Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epitopes of KL-6(MUC1) monoclonal antibody.21
222609952012Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules.5
218806692012Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epitopes of KL-6(MUC1) monoclonal antibody.21
222609952012Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules.5
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.58
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.58
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
186986292008Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.16
186986292008Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.16
176901042007Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.25
176901042007Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.25
164954842006Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.8
164954842006Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.8
153243042004Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.1

Citation

Dessen P

CHST1 (carbohydrate sulfotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61819/deep-insight-explorer/meetings/gene-fusions-explorer/