CLEC16A (C-type lectin domain containing 16A)

2014-11-01  

Identity

HGNC
CLEC16A
LOCATION
16p13.13
LOCUSID
23274
ALIAS
Gop-1,KIAA0350
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23274
MIM: 611303
HGNC: 29013
Ensembl: ENSG00000038532

Variants:

dbSNP: 23274
ClinVar: 23274
TCGA: ENSG00000038532
COSMIC: CLEC16A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000038532ENST00000261657H7BXG1
ENSG00000038532ENST00000409552Q2KHT3
ENSG00000038532ENST00000409790Q2KHT3
ENSG00000038532ENST00000428742H7BZI2
ENSG00000038532ENST00000436973H7BZJ9
ENSG00000038532ENST00000459723A0A2R8YDG4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
356041102023An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy.5
365380412023CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.5
366227932023CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.0
371759302023CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.7
356041102023An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy.5
365380412023CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.5
366227932023CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.0
371759302023CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.7
346439572021Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells.3
346439572021Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells.3
326413842020The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.8
332322982020Mitophagy protects β cells from inflammatory damage in diabetes.51
326413842020The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.8
332322982020Mitophagy protects β cells from inflammatory damage in diabetes.51
307746292019The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.11

Citation

Dessen P

CLEC16A (C-type lectin domain containing 16A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61865/case-report-explorer/cancer-prone-explorer/