DUSP18 (dual specificity phosphatase 18)

2014-11-01  

Identity

HGNC
DUSP18
LOCATION
22q12.2
LOCUSID
150290
ALIAS
DSP18,DUSP20,LMWDSP20

Other Information

Locus ID:

NCBI: 150290
MIM: 611446
HGNC: 18484
Ensembl: ENSG00000167065

Variants:

dbSNP: 150290
ClinVar: 150290
TCGA: ENSG00000167065
COSMIC: DUSP18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167065ENST00000334679Q8NEJ0
ENSG00000167065ENST00000334679A0A024R1L2
ENSG00000167065ENST00000342474F8VX42
ENSG00000167065ENST00000377087Q8NEJ0
ENSG00000167065ENST00000377087A0A024R1L2
ENSG00000167065ENST00000403268F2Z2P2
ENSG00000167065ENST00000404885Q8NEJ0
ENSG00000167065ENST00000404885A0A024R1L2
ENSG00000167065ENST00000407308Q8NEJ0
ENSG00000167065ENST00000407308A0A024R1L2
ENSG00000167065ENST00000430175H7C401
ENSG00000167065ENST00000442752C9JEE9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
358416932022Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion.3
358416932022Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion.3
298521742018Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1.4
298521742018Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1.4
166991842006Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.5
167203442006Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo.6
166991842006Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.5
167203442006Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo.6
125916172003Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain.3
125916172003Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain.3

Citation

Dessen P

DUSP18 (dual specificity phosphatase 18)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62676/meetings/case-report-explorer/