EDC4 (enhancer of mRNA decapping 4)

2014-11-01  

Identity

HGNC
EDC4
LOCATION
16q22.1
LOCUSID
23644
ALIAS
GE1,Ge-1,HEDL5,HEDLS,RCD-8,RCD8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23644
MIM: 606030
HGNC: 17157
Ensembl: ENSG00000038358

Variants:

dbSNP: 23644
ClinVar: 23644
TCGA: ENSG00000038358
COSMIC: EDC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000038358ENST00000358933Q6P2E9
ENSG00000038358ENST00000573985I3L0V0
ENSG00000038358ENST00000575033I3L3M2
ENSG00000038358ENST00000577105I3L2F4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
325103232020A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.8
330548582020Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage.5
325103232020A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.8
330548582020Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage.5
295112132018Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.20
295112132018Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.20
259703282015The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.10
259703282015The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.10
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.55
247559892014LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.12
248585632014CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.12
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.55
247559892014LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.12
248585632014CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.12
229828642012EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.12

Citation

Dessen P

EDC4 (enhancer of mRNA decapping 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62724/gene-fusions/haematological-explorer/deep-insight-explorer/