EHD4 (EH domain containing 4)

2014-11-01  

Identity

HGNC
EHD4
LOCATION
15q15.1
LOCUSID
30844
ALIAS
PAST4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 30844
MIM: 605892
HGNC: 3245
Ensembl: ENSG00000103966

Variants:

dbSNP: 30844
ClinVar: 30844
TCGA: ENSG00000103966
COSMIC: EHD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103966ENST00000220325Q9H223
ENSG00000103966ENST00000220325A0A024R9N6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
339725312021A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.16
339725312021A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.16
328003452020Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4.0
329663362020Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.6
328003452020Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4.0
329663362020Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.6
233256862013Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity.26
240195282013Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.37
233256862013Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity.26
240195282013Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.37
211873872011Trk retrograde signaling requires persistent, Pincher-directed endosomes.30
211873872011Trk retrograde signaling requires persistent, Pincher-directed endosomes.30
204891642010EH domain proteins regulate cardiac membrane protein targeting.46
204891642010EH domain proteins regulate cardiac membrane protein targeting.46
183314522008A role for EHD4 in the regulation of early endosomal transport.78

Citation

Dessen P

EHD4 (EH domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62763/deep-insight-explorer/meetings/