ERI1 (exoribonuclease 1)

2014-11-01 Affiliation

Identity

HGNC

ERI1

LOCATION

8p23.1

LOCUSID

90459

ALIAS

3HEXO,HEXO,THEX1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 90459
MIM: 608739
HGNC: 23994
Ensembl: ENSG00000104626

Variants:

dbSNP: 90459
ClinVar: 90459
TCGA: ENSG00000104626
COSMIC: ERI1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104626	ENST00000250263	Q8IV48
ENSG00000104626	ENST00000250263	A0A024R355
ENSG00000104626	ENST00000519292	Q8IV48
ENSG00000104626	ENST00000519292	A0A024R355
ENSG00000104626	ENST00000520684	E5RIV7
ENSG00000104626	ENST00000521844	E5RJM3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37352860	2023	Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.	0
37352860	2023	Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.	0
32960265	2020	Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.	4
32960265	2020	Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.	4
23329046	2013	Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.	67
23329046	2013	Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.	67
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
16912046	2006	Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA.	35
16912046	2006	Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA.	35
14961122	2004	A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.	256
15451662	2004	Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP.	22
14961122	2004	A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.	256
15451662	2004	Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP.	22
14536070	2003	A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.	69

Citation

Dessen P

ERI1 (exoribonuclease 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62880/favicon/haematological-explorer/