EXOC6 (exocyst complex component 6)

2014-11-01  

Identity

HGNC
EXOC6
LOCATION
10q23.33
LOCUSID
54536
ALIAS
EXOC6A,SEC15,SEC15L,SEC15L1,SEC15L3,Sec15p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54536
MIM: 609672
HGNC: 23196
Ensembl: ENSG00000138190

Variants:

dbSNP: 54536
ClinVar: 54536
TCGA: ENSG00000138190
COSMIC: EXOC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138190ENST00000260762Q8TAG9
ENSG00000138190ENST00000371543B1AP46
ENSG00000138190ENST00000371552Q8TAG9
ENSG00000138190ENST00000443748E7EW84
ENSG00000138190ENST00000458552H0Y5J8
ENSG00000138190ENST00000495132F2Z3K0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
234355662013NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.53
234355662013NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.53
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
209447472010Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.60
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
209447472010Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.60
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
164787832006The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit.23
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
164787832006The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit.23
152922012004Sec15 is an effector for the Rab11 GTPase in mammalian cells.130
152922012004Sec15 is an effector for the Rab11 GTPase in mammalian cells.130

Citation

Dessen P

EXOC6 (exocyst complex component 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62946/gene-fusions-explorer/