FITM2 (fat storage inducing transmembrane protein 2)

2014-11-01  

Identity

HGNC
FITM2
LOCATION
20q13.12
LOCUSID
128486
ALIAS
C20orf142,Fit2,SIDDIS,dJ881L22.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 128486
MIM: 612029
HGNC: 16135
Ensembl: ENSG00000197296

Variants:

dbSNP: 128486
ClinVar: 128486
TCGA: ENSG00000197296
COSMIC: FITM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197296ENST00000396825Q8N6M3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923

References

Pubmed IDYearTitleCitations
338613192021FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.18
346723582021High FITM2 expression promotes cell migration ability of hepatocellular carcinoma by regulating the formation of caveolae and indicates poor patient survival.6
338613192021FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.18
346723582021High FITM2 expression promotes cell migration ability of hepatocellular carcinoma by regulating the formation of caveolae and indicates poor patient survival.6
329159492020FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.18
329159492020FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.18
300208282019Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.7
300208282019Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.7
280676222017A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy.13
280676222017A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy.13
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20

Citation

Dessen P

FITM2 (fat storage inducing transmembrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63389/tumors-explorer/js/humanGenome