GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23163
MIM: 606006
HGNC: 17079
Ensembl: ENSG00000125447

Variants:

dbSNP: 23163
ClinVar: 23163
TCGA: ENSG00000125447
COSMIC: GGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125447ENST00000537686Q9NZ52
ENSG00000125447ENST00000538886Q9NZ52
ENSG00000125447ENST00000577435G3V1K5
ENSG00000125447ENST00000578348Q9NZ52
ENSG00000125447ENST00000578773J3QRK7
ENSG00000125447ENST00000579743A0A087WYN2
ENSG00000125447ENST00000580646J3QS87
ENSG00000125447ENST00000580799J3KSG3
ENSG00000125447ENST00000582376J3QRS8
ENSG00000125447ENST00000582486J3KSS7
ENSG00000125447ENST00000582717Q9NZ52
ENSG00000125447ENST00000583282J3KTR5
ENSG00000125447ENST00000584243J3QRP3
ENSG00000125447ENST00000584550J3KS27
ENSG00000125447ENST00000621217B7Z1E9
ENSG00000125447ENST00000621870G3V1K5
ENSG00000125447ENST00000649398Q9NZ52

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Signaling by METREACTOMER-HSA-6806834
MET receptor recyclingREACTOMER-HSA-8875656
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371414372023Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?0
371414372023Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?0
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
323340262020GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.0
323340262020GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.0
292734632019Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population.5
292734632019Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population.5
268113292016GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.20
269359702016Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.15
268113292016GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.20
269359702016Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.15
264468452015GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.9
264468452015GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.9
244072852014Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.11

Citation

Dessen P

GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63765/favicon/cancer-prone-explorer/gene-fusions/?id=63765