GPR15 (G protein-coupled receptor 15)

2014-11-01  

Identity

HGNC
GPR15
LOCATION
3q11.2
LOCUSID
2838
ALIAS
BOB

Other Information

Locus ID:

NCBI: 2838
MIM: 601166
HGNC: 4469
Ensembl: ENSG00000154165

Variants:

dbSNP: 2838
ClinVar: 2838
TCGA: ENSG00000154165
COSMIC: GPR15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154165ENST00000284311P49685
ENSG00000154165ENST00000284311B6V9G9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374577322023Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.0
374577322023Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.0
361648082022GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium.2
365513272022Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease.0
361648082022GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium.2
365513272022Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease.0
333101552021Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking.2
334316972021Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.8
336747642021The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15.11
337272292021GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer.12
343896132021Clonally expanded, GPR15-expressing pathogenic effector T(H)2 cells are associated with eosinophilic esophagitis.34
333101552021Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking.2
334316972021Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.8
336747642021The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15.11
337272292021GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer.12

Citation

Dessen P

GPR15 (G protein-coupled receptor 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63966/gene-fusions-explorer/gene-explorer/