ANGPTL2 (angiopoietin like 2)

2003-11-01  

Identity

HGNC
ANGPTL2
LOCATION
9q33.3
LOCUSID
23452
ALIAS
ARP2,HARP

Other Information

Locus ID:

NCBI: 23452
MIM: 605001
HGNC: 490
Ensembl: ENSG00000136859

Variants:

dbSNP: 23452
ClinVar: 23452
TCGA: ENSG00000136859
COSMIC: ANGPTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136859ENST00000373417Q9UKU9
ENSG00000136859ENST00000373425Q9UKU9
ENSG00000136859ENST00000373425A0A024R868

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369170862023ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis.7
369170862023ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis.7
347096602022Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.1
347096602022Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.1
328131092021Vitreous levels of vascular endothelial growth factor, stromal cell-derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy.5
330515962021Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis.7
335081202021CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.5
340005142021Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.7
348301122021Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence.7
328131092021Vitreous levels of vascular endothelial growth factor, stromal cell-derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy.5
330515962021Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis.7
335081202021CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.5
340005142021Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.7
348301122021Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence.7
318401732020Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.5

Citation

Dessen P

ANGPTL2 (angiopoietin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/640/case-report-explorer/haematological-explorer/