GREM2 (gremlin 2, DAN family BMP antagonist)

2014-11-01 Affiliation

Identity

HGNC

GREM2

LOCATION

1q43

LOCUSID

64388

ALIAS

CKTSF1B2,DAND3,PRDC,STHAG9

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64388
MIM: 608832
HGNC: 17655
Ensembl: ENSG00000180875

Variants:

dbSNP: 64388
ClinVar: 64388
TCGA: ENSG00000180875
COSMIC: GREM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000180875	ENST00000318160	Q9H772
ENSG00000180875	ENST00000318160	A0A024R3Y1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by BMP	REACTOME	R-HSA-201451

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448320	allopurinol	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	30924126

References

Pubmed ID	Year	Title	Citations
35349825	2022	GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning.	3
35619575	2022	MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression.	4
35349825	2022	GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning.	3
35619575	2022	MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression.	4
33369218	2021	Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis.	3
33369218	2021	Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis.	3
32297643	2020	Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women.	3
33144675	2020	Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway.	48
32297643	2020	Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women.	3
33144675	2020	Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway.	48
30831151	2019	Grem2 mediates podocyte apoptosis in high glucose milieu.	9
30831151	2019	Grem2 mediates podocyte apoptosis in high glucose milieu.	9
28992378	2018	GREM2 nucleotide variants and the risk of tooth agenesis.	5
30014930	2018	Association betweenGREM2 gene polymorphism with osteoporosis and osteopenia in postmenopausal women.	5
30246922	2018	Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis.	9

Citation

Dessen P

GREM2 (gremlin 2, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64033/cancer-prone-explorer/gene-fusions-explorer/