HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)

2014-11-01  

Identity

HGNC
HNRNPA3
LOCATION
2q31.2
LOCUSID
220988
ALIAS
2610510D13Rik,D10S102,FBRNP,HNRPA3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 220988
MIM: 605372
HGNC: 24941
Ensembl: ENSG00000170144

Variants:

dbSNP: 220988
ClinVar: 220988
TCGA: ENSG00000170144
COSMIC: HNRNPA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170144ENST00000392524P51991
ENSG00000170144ENST00000392524A0A384NL63
ENSG00000170144ENST00000411529P51991
ENSG00000170144ENST00000411529B4DDB6
ENSG00000170144ENST00000432457H7C1J8
ENSG00000170144ENST00000435711P51991
ENSG00000170144ENST00000435711A0A384NL63

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334690082021Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.14
334690082021Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.14
323217122020Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.6
323217122020Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.6
296937452018Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.9
296937452018Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.9
284315752017Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.16
291311082017Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.14
284315752017Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.16
291311082017Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.14
274612522016Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.29
274612522016Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.29
238275242013Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis.11
238275242013Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis.11
225465102012Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.9

Citation

Dessen P

HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64368/gene-fusions-explorer/welcome