HYPK (huntingtin interacting protein K)

2014-11-01  

Identity

HGNC
HYPK
LOCATION
15q15.3
LOCUSID
25764
ALIAS
C15orf63,HSPC136
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25764
MIM: 612784
HGNC: 18418
Ensembl: ENSG00000242028

Variants:

dbSNP: 25764
ClinVar: 25764
TCGA: ENSG00000242028
COSMIC: HYPK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242028ENST00000406925Q9NX55
ENSG00000242028ENST00000442995Q9NX55
ENSG00000242028ENST00000458412J3QT56

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
386570472024HYPK: A marginally disordered protein sensitive to charge decoration.0
386570472024HYPK: A marginally disordered protein sensitive to charge decoration.0
348364902022HYPK coordinates degradation of polyneddylated proteins by autophagy.7
358578682022Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane.3
348364902022HYPK coordinates degradation of polyneddylated proteins by autophagy.7
358578682022Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane.3
320420622020Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.20
320420622020Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.20
313976272019An IRES-dependent translation of HYPK mRNA generates a truncated isoform of the protein that lacks the nuclear localization and functional ability.3
313976272019An IRES-dependent translation of HYPK mRNA generates a truncated isoform of the protein that lacks the nuclear localization and functional ability.3
293813482018Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.10
297548252018Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.37
302516732018Metastable states of HYPK-UBA domain's seeds drive the dynamics of its own aggregation.6
293813482018Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.10
297548252018Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.37

Citation

Dessen P

HYPK (huntingtin interacting protein K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64482/js/img/humanGenome