JCHAIN (joining chain of multimeric IgA and IgM)

2014-11-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
IGCJ,IGJ,JCH
FUSION GENES

Other Information

Locus ID:

NCBI: 3512
MIM: 147790
HGNC: 5713
Ensembl: ENSG00000132465

Variants:

dbSNP: 3512
ClinVar: 3512
TCGA: ENSG00000132465
COSMIC: JCHAIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132465ENST00000254801P01591
ENSG00000132465ENST00000391614D6RHJ6
ENSG00000132465ENST00000470866C9JA05
ENSG00000132465ENST00000510437P01591
ENSG00000132465ENST00000510614D6RD17
ENSG00000132465ENST00000543780P01591

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375397062023IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.0
375397062023IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.0
270445432016High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.13
270445432016High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.13
209474332011Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.18
209474332011Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.18
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37

Citation

Dessen P

JCHAIN (joining chain of multimeric IgA and IgM)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64558/img/case-report-explorer/haematological-explorer/