INMT (indolethylamine N-methyltransferase)

2014-11-01  

Identity

HGNC
INMT
LOCATION
7p14.3
LOCUSID
11185
ALIAS
TEMT

Other Information

Locus ID:

NCBI: 11185
MIM: 604854
HGNC: 6069
Ensembl: ENSG00000241644

Variants:

dbSNP: 11185
ClinVar: 11185
TCGA: ENSG00000241644
COSMIC: INMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241644ENST00000013222O95050
ENSG00000241644ENST00000409539O95050

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Selenocompound metabolismKEGGko00450
Tryptophan metabolismKEGGhsa00380
Selenocompound metabolismKEGGhsa00450
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Methylation of MeSeH for excretionREACTOMER-HSA-2408552

References

Pubmed IDYearTitleCitations
381598532024Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion.1
381598532024Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion.1
345879772021Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer.8
345879772021Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer.8
313106422019Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.5
313106422019Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.5
261830642015Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease.5
265379462015Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene.15
261830642015Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease.5
265379462015Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

INMT (indolethylamine N-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64619/tumors-explorer/js/gene-fusions-explorer/