KCNK12 (potassium two pore domain channel subfamily K member 12)

2014-11-01  

Identity

HGNC
LOCATION
2p16.3
LOCUSID
ALIAS
K2p12.1,THIK-2,THIK2

Other Information

Locus ID:

NCBI: 56660
MIM: 607366
HGNC: 6274
Ensembl: ENSG00000184261

Variants:

dbSNP: 56660
ClinVar: 56660
TCGA: ENSG00000184261
COSMIC: KCNK12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184261ENST00000327876Q9HB15

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
370995392023Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors.0
370995392023Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors.0
251486872014Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.25
251486872014Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.25
241633672013Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.14
241633672013Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.14
182094732008Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.5
186769882008A high-density association screen of 155 ion transport genes for involvement with common migraine.31
182094732008Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.5
186769882008A high-density association screen of 155 ion transport genes for involvement with common migraine.31

Citation

Dessen P

KCNK12 (potassium two pore domain channel subfamily K member 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64794/teaching-explorer/gene-explorer/