DDX6 (DEAD-box helicase 6)

2003-02-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
HLR2,IDDILF,P54,RCK,Rck/p54
FUSION GENES

Other Information

Locus ID:

NCBI: 1656
MIM: 600326
HGNC: 2747
Ensembl: ENSG00000110367

Variants:

dbSNP: 1656
ClinVar: 1656
TCGA: ENSG00000110367
COSMIC: DDX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110367ENST00000526070P26196
ENSG00000110367ENST00000534980P26196
ENSG00000110367ENST00000617381Q8IV96
ENSG00000110367ENST00000620157P26196

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383779442024DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.0
385360352024DDX6 modulates P-body and stress granule assembly, composition, and docking.0
385516422024The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.0
388349472024Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.0
383779442024DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.0
385360352024DDX6 modulates P-body and stress granule assembly, composition, and docking.0
385516422024The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.0
388349472024Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.0
363228272023miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.2
368346092023RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.3
374277912023RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.6
363228272023miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.2
368346092023RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.3
374277912023RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.6
359744452022Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS.1

Citation

Dessen P

DDX6 (DEAD-box helicase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/65/deep-insight-explorer/css/lib/gene-explorer/