APBB1 (amyloid beta precursor protein binding family B member 1)

2003-06-01  

Identity

HGNC
APBB1
LOCATION
11p15.4
LOCUSID
322
ALIAS
FE65,MGC:9072,RIR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 322
MIM: 602709
HGNC: 581
Ensembl: ENSG00000166313

Variants:

dbSNP: 322
ClinVar: 322
TCGA: ENSG00000166313
COSMIC: APBB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166313ENST00000299402O00213
ENSG00000166313ENST00000311051O00213
ENSG00000166313ENST00000389906J3KPL8
ENSG00000166313ENST00000529519V9GYR7
ENSG00000166313ENST00000529890V9GY97
ENSG00000166313ENST00000530885O00213
ENSG00000166313ENST00000532020V9GYD5
ENSG00000166313ENST00000608394O00213
ENSG00000166313ENST00000608435A0A075B7G8
ENSG00000166313ENST00000608645O00213
ENSG00000166313ENST00000608655O00213
ENSG00000166313ENST00000608704O00213
ENSG00000166313ENST00000609331O00213
ENSG00000166313ENST00000609360O00213
ENSG00000166313ENST00000610474A0A087X0V7
ENSG00000166313ENST00000618005A0A087X0V7
ENSG00000166313ENST00000621678A0A087WYH9

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379185522023Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.0
379185522023Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.0
330473932020ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.8
331239062020Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway.2
330473932020ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.8
331239062020Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway.2
296154912018Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.13
296154912018Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.13
278365462017APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells.9
283238442017Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.5
289635162017Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.9
278365462017APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells.9
283238442017Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.5
289635162017Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.9
271760722016Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.2

Citation

Dessen P

APBB1 (amyloid beta precursor protein binding family B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/665/favicon/teaching-explorer/haematological-explorer/