ATG4C (autophagy related 4C cysteine peptidase)

2003-10-01  

Identity

HGNC
ATG4C
LOCATION
1p31.3
LOCUSID
84938
ALIAS
APG4-C,APG4C,AUTL1,AUTL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84938
MIM: 611339
HGNC: 16040
Ensembl: ENSG00000125703

Variants:

dbSNP: 84938
ClinVar: 84938
TCGA: ENSG00000125703
COSMIC: ATG4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125703ENST00000317868Q96DT6
ENSG00000125703ENST00000317868A0A384MTY5
ENSG00000125703ENST00000371118A6NGQ4
ENSG00000125703ENST00000371120Q96DT6
ENSG00000125703ENST00000371120A0A384MTY5
ENSG00000125703ENST00000414558H7BZW5
ENSG00000125703ENST00000443289C9JC51

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
346194952021MicroRNA-142-3p inhibits autophagy and promotes intracellular survival of Mycobacterium tuberculosis by targeting ATG16L1 and ATG4c.9
346993122021Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression.6
337731062021ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.27
346194952021MicroRNA-142-3p inhibits autophagy and promotes intracellular survival of Mycobacterium tuberculosis by targeting ATG16L1 and ATG4c.9
346993122021Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression.6
324017682020Clinicopathological and prognostic significance of caveolin-1 and ATG4C expression in the epithelial ovarian cancer.3
324017682020Clinicopathological and prognostic significance of caveolin-1 and ATG4C expression in the epithelial ovarian cancer.3
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.93
312919882019Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.28
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.93
312919882019Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.28
277425322017Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease.11
284235112017ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.26
277425322017Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease.11

Citation

Dessen P

ATG4C (autophagy related 4C cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/673/teaching-explorer/humanGenome