ASB2 (ankyrin repeat and SOCS box containing 2)

2003-12-01  

Identity

HGNC
ASB2
LOCATION
14q32.12
LOCUSID
51676
ALIAS
ASB-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51676
MIM: 605759
HGNC: 16012
Ensembl: ENSG00000100628

Variants:

dbSNP: 51676
ClinVar: 51676
TCGA: ENSG00000100628
COSMIC: ASB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100628ENST00000315988Q96Q27
ENSG00000100628ENST00000555019Q96Q27
ENSG00000100628ENST00000555019A0A024R6E7
ENSG00000100628ENST00000555287G3V484
ENSG00000100628ENST00000555507G3V2Z2
ENSG00000100628ENST00000556062G3V4B2
ENSG00000100628ENST00000557613G3V3P8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
299550392018High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.11
301162722018The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.14
299550392018High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.11
301162722018The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.14
265376332015Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.8
265376332015Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.8
240449202013Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation.3
240522622013ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.10
240449202013Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation.3
240522622013ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.10
221741542012ECSASB2 mediates MLL degradation during hematopoietic differentiation.32
223820222012The ASB2β Ubiquitin-interacting motif is involved in its monoubiquitination.1
229163082012Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.5
221741542012ECSASB2 mediates MLL degradation during hematopoietic differentiation.32
223820222012The ASB2β Ubiquitin-interacting motif is involved in its monoubiquitination.1

Citation

Dessen P

ASB2 (ankyrin repeat and SOCS box containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/711/case-report-explorer/case-report-explorer/