OPN5 (opsin 5)

2014-11-01  

Identity

HGNC
LOCATION
6p12.3
LOCUSID
ALIAS
GPR136,GRP136,PGR12,TMEM13

Other Information

Locus ID:

NCBI: 221391
MIM: 609042
HGNC: 19992
Ensembl: ENSG00000124818

Variants:

dbSNP: 221391
ClinVar: 221391
TCGA: ENSG00000124818
COSMIC: OPN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124818ENST00000371211Q6U736
ENSG00000124818ENST00000393699J3KPQ2
ENSG00000124818ENST00000489301D6RDV4
ENSG00000124818ENST00000638973Q6U736

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
OpsinsREACTOMER-HSA-419771
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
324143242020Neuropsin in mental health.3
324143242020Neuropsin in mental health.3
286365782017Human neuropsin gene in depression.7
286365782017Human neuropsin gene in depression.7
244030722014Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.38
246146392014[Neuropsin signaling as a novel therapeutic target of schizophrenia].0
249419102014Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5.11
244030722014Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.38
246146392014[Neuropsin signaling as a novel therapeutic target of schizophrenia].0
249419102014Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5.11
220433192011UV-sensitive photoreceptor protein OPN5 in humans and mice.89
220433192011UV-sensitive photoreceptor protein OPN5 in humans and mice.89
183543912008Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.16
183543912008Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.16

Citation

Dessen P

OPN5 (opsin 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71136/js/lib/tumors-explorer/