PRMT8 (protein arginine methyltransferase 8)

2014-11-01 Affiliation

Identity

HGNC

PRMT8

LOCATION

12p13.32

LOCUSID

56341

ALIAS

HRMT1L3,HRMT1L4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 56341
MIM: 610086
HGNC: 5188
Ensembl: ENSG00000111218

Variants:

dbSNP: 56341
ClinVar: 56341
TCGA: ENSG00000111218
COSMIC: PRMT8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111218	ENST00000382622	Q9NR22
ENSG00000111218	ENST00000452611	Q9NR22

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28543863	2017	PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis.	18
28543863	2017	PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis.	18
26876602	2016	Novel helical assembly in arginine methyltransferase 8.	11
26876602	2016	Novel helical assembly in arginine methyltransferase 8.	11
23620769	2013	Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.	49
23635657	2013	Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.	6
23946480	2013	Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.	23
23620769	2013	Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.	49
23635657	2013	Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.	6
23946480	2013	Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.	23
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19060911	2009	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	444
19060911	2009	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	444
18320585	2008	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	27

Citation

Dessen P

PRMT8 (protein arginine methyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72221/haematological-explorer/gene-explorer/