ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)

2003-06-01  

Identity

HGNC
ATP2A2
LOCATION
12q24.11
LOCUSID
488
ALIAS
ATP2B,DAR,DD,SERCA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 488
MIM: 108740
HGNC: 812
Ensembl: ENSG00000174437

Variants:

dbSNP: 488
ClinVar: 488
TCGA: ENSG00000174437
COSMIC: ATP2A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174437ENST00000308664P16615
ENSG00000174437ENST00000377685J3QSY6
ENSG00000174437ENST00000539276P16615
ENSG00000174437ENST00000539276A0A0S2Z3L2
ENSG00000174437ENST00000548169H7C5W9
ENSG00000174437ENST00000552636F8W1Z7
ENSG00000174437ENST00000553144A0A0C4DH86

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Alzheimer's diseaseKEGGko05010
Calcium signaling pathwayKEGGhsa04020
Alzheimer's diseaseKEGGhsa05010
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Thyroid hormone signaling pathwayKEGGhsa04919
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
383398352024IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.0
383398352024IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.0
368349242023Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.1
368764892023Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.4
371325262023Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity.0
371957062023Association of Somatic ATP2A2 Damaging Variants With Grover Disease.5
372910922023SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases.0
375724312023SERCA2 phosphorylation at the heart of the disease.1
377383622023Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8(+) T cell metabolic fitness and function in tumors.4
368349242023Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.1
368764892023Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.4
371325262023Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity.0
371957062023Association of Somatic ATP2A2 Damaging Variants With Grover Disease.5
372910922023SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases.0
375724312023SERCA2 phosphorylation at the heart of the disease.1

Citation

Dessen P

ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/723/gene-fusions/cancer-prone-explorer/gene-fusions-explorer/