RHBG (Rh family B glycoprotein)

2014-11-01  

Identity

HGNC
RHBG
LOCATION
1q22
LOCUSID
57127
ALIAS
SLC42A2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57127
MIM: 607079
HGNC: 14572
Ensembl: ENSG00000132677

Variants:

dbSNP: 57127
ClinVar: 57127
TCGA: ENSG00000132677
COSMIC: RHBG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132677ENST00000451864F6Q468
ENSG00000132677ENST00000537040Q9H310
ENSG00000132677ENST00000612897A0A087WTF7
ENSG00000132677ENST00000613460F6Q468
ENSG00000132677ENST00000620376A0A087WUR4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Rhesus glycoproteins mediate ammonium transport.REACTOMER-HSA-444411

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
390528342024Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB.0
390528342024Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB.0
256166632015Evidence of a structural and functional ammonium transporter RhBG·anion exchanger 1·ankyrin-G complex in kidney epithelial cells.8
260298882015Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.9
256166632015Evidence of a structural and functional ammonium transporter RhBG·anion exchanger 1·ankyrin-G complex in kidney epithelial cells.8
260298882015Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.9
246477132014Ammonia transport in the kidney by Rhesus glycoproteins.34
246477132014Ammonia transport in the kidney by Rhesus glycoproteins.34
233241762013Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.17
240779892013Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.21
233241762013Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.17
240779892013Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.21
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
193571822009RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels.18

Citation

Dessen P

RHBG (Rh family B glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72627/js/gene-fusions-explorer/