RNASEH1 (ribonuclease H1)

2014-11-01  

Identity

HGNC
RNASEH1
LOCATION
2p25.3
LOCUSID
246243
ALIAS
H1RNA,PEOB2,RNH1

Other Information

Locus ID:

NCBI: 246243
MIM: 604123
HGNC: 18466
Ensembl: ENSG00000171865

Variants:

dbSNP: 246243
ClinVar: 246243
TCGA: ENSG00000171865
COSMIC: RNASEH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171865ENST00000315212O60930
ENSG00000171865ENST00000315212E5KN15
ENSG00000171865ENST00000436842F8WD93
ENSG00000171865ENST00000454734F8WBP0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
DNA replicationKEGGhsa03030

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370225172023A pan-cancer analysis of RNASEH1, a potential regulator of the tumor microenvironment.2
373784202023RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.1
370225172023A pan-cancer analysis of RNASEH1, a potential regulator of the tumor microenvironment.2
373784202023RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.1
343481522021BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.14
343481522021BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.14
324478042020A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia.0
333964182020Progressive External Ophthalmoplegia in Polish Patients-From Clinical Evaluation to Genetic Confirmation.1
324478042020A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia.0
333964182020Progressive External Ophthalmoplegia in Polish Patients-From Clinical Evaluation to Genetic Confirmation.1
306054512019RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.34
314958752019Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.19
306054512019RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.34
314958752019Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.19
292049162018RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia.2

Citation

Dessen P

RNASEH1 (ribonuclease H1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72673/cancer-prone-explorer/humanGenome