SLC28A2 (solute carrier family 28 member 2)

2014-11-01 Affiliation

Identity

HGNC

SLC28A2

LOCATION

15q21.1

LOCUSID

9153

ALIAS

CNT2,HCNT2,HsT17153,SPNT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9153
MIM: 606208
HGNC: 11002
Ensembl: ENSG00000137860

Variants:

dbSNP: 9153
ClinVar: 9153
TCGA: ENSG00000137860
COSMIC: SLC28A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137860	ENST00000347644	O43868
ENSG00000137860	ENST00000559924	H0YNK4
ENSG00000137860	ENST00000560438	H0YNM6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	REACTOME	R-HSA-83936

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA162263533	nephrotoxicity	Disease	ClinicalAnnotation	associated	PD	31619748
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation	associated	PD	26071337
PA165948902	boceprevir	Chemical	MultilinkAnnotation	associated		25836019
PA166201941	tenofovir disoproxil fumarate	Chemical	ClinicalAnnotation	associated	PD	31619748
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated	PD	18538445
PA444445	Hepatitis C	Disease	ClinicalAnnotation	associated	PD	26071337
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PD	18538445, 20665488
PA447230	HIV Infections	Disease	ClinicalAnnotation	associated	PD	31619748
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated	PD	18538445, 20665488
PA451159	protease inhibitors	Chemical	ClinicalAnnotation	associated	PD	26071337
PA451241	ribavirin	Chemical	ClinicalAnnotation	associated	PD	26071337

References

Pubmed ID	Year	Title	Citations
33910126	2021	Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.	5
33910126	2021	Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.	5
30679935	2019	Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese.	4
30679935	2019	Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese.	4
28385889	2017	Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.	7
28385889	2017	Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.	7
23195617	2013	Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection.	14
23195617	2013	Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection.	14
23149444	2012	Negative predictive value of IL28B, SLC28A2, and CYP27B1 SNPs and low RBV plasma exposure for therapeutic response to PEG/IFN-RBV treatment.	2
23149444	2012	Negative predictive value of IL28B, SLC28A2, and CYP27B1 SNPs and low RBV plasma exposure for therapeutic response to PEG/IFN-RBV treatment.	2
20028759	2010	Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.	37
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20392501	2010	Contribution of adenosine related genes to the risk of depression with disturbed sleep.	23
20506327	2010	Link between high-affinity adenosine concentrative nucleoside transporter-2 (CNT2) and energy metabolism in intestinal and liver parenchymal cells.	8
20028759	2010	Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.	37

Citation

Dessen P

SLC28A2 (solute carrier family 28 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73381/gene-explorer/humanGenome