SLC30A3 (solute carrier family 30 member 3)

2014-11-01  

Identity

HGNC
SLC30A3
LOCATION
2p23.3
LOCUSID
7781
ALIAS
ZNT3

Other Information

Locus ID:

NCBI: 7781
MIM: 602878
HGNC: 11014
Ensembl: ENSG00000115194

Variants:

dbSNP: 7781
ClinVar: 7781
TCGA: ENSG00000115194
COSMIC: SLC30A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115194ENST00000233535Q99726
ENSG00000115194ENST00000424577C9JHX4
ENSG00000115194ENST00000426569C9J1K4
ENSG00000115194ENST00000426924C9JV68
ENSG00000115194ENST00000432351C9JM13
ENSG00000115194ENST00000445870H7BZ83
ENSG00000115194ENST00000450118C9JHZ9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337152702021Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma.6
337152702021Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma.6
329250492020Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.9
329250492020Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.9
293723702018SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the β-cells.4
293723702018SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the β-cells.4
268679002016The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression.8
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
276782942016Protective roles of SLC30A3 against endoplasmic reticulum stress via ERK1/2 activation.6
277501162016Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples.9
268679002016The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression.8
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
276782942016Protective roles of SLC30A3 against endoplasmic reticulum stress via ERK1/2 activation.6
277501162016Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples.9
249538732015Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.21

Citation

Dessen P

SLC30A3 (solute carrier family 30 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73389/img/css/favicon/manifest.json