SLC30A5 (solute carrier family 30 member 5)

2014-11-01  

Identity

HGNC
SLC30A5
LOCATION
5q13.1
LOCUSID
64924
ALIAS
ZNT5,ZNTL1,ZTL1,ZnT-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64924
MIM: 607819
HGNC: 19089
Ensembl: ENSG00000145740

Variants:

dbSNP: 64924
ClinVar: 64924
TCGA: ENSG00000145740
COSMIC: SLC30A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145740ENST00000380860Q8TAD4
ENSG00000145740ENST00000396591Q8TAD4
ENSG00000145740ENST00000502979Q8TAD4
ENSG00000145740ENST00000504103D6REM2
ENSG00000145740ENST00000511158H0Y957
ENSG00000145740ENST00000513937H0YAH4
ENSG00000145740ENST00000621204Q9BY48

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335474252021Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy.7
335474252021Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy.7
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
276614182016Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.11
232750322013Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.8
232750322013Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.8
225293532012Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.64
225293532012Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.64
218873372011Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions.9
218873372011Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions.9
206898072010Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.27
206898072010Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.27
197590142009Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.53
197590142009Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.53
179715002008Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.30

Citation

Dessen P

SLC30A5 (solute carrier family 30 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73390/humanGenome