SLC7A10 (solute carrier family 7 member 10)

2014-11-01  

Identity

HGNC
SLC7A10
LOCATION
19q13.11
LOCUSID
56301
ALIAS
ASC1,HASC-1,asc-1

Other Information

Locus ID:

NCBI: 56301
MIM: 607959
HGNC: 11058
Ensembl: ENSG00000130876

Variants:

dbSNP: 56301
ClinVar: 56301
TCGA: ENSG00000130876
COSMIC: SLC7A10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130876ENST00000253188Q9NS82
ENSG00000130876ENST00000587064K7ENB6
ENSG00000130876ENST00000590036K7EK24
ENSG00000130876ENST00000592596K7ENB6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
369168782023Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.5
379036192023Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human Pathologies, Human Startle Disease, and Developmental Delay.1
369168782023Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.5
379036192023Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human Pathologies, Human Startle Disease, and Developmental Delay.1
341976272021ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation.12
341976272021ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation.12
317940732020ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy.8
321119192020Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism.9
323972362020NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y(2)R Activation in Breast Cancer Cells.18
317940732020ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy.8
321119192020Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism.9
323972362020NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y(2)R Activation in Breast Cancer Cells.18
250804782014ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.99
252194982014Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.95
250804782014ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.99

Citation

Dessen P

SLC7A10 (solute carrier family 7 member 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73481/css/lib/gene-fusions-explorer/