SLC9A5 (solute carrier family 9 member A5)

2014-11-01  

Identity

HGNC
SLC9A5
LOCATION
16q22.1
LOCUSID
6553
ALIAS
NHE5

Other Information

Locus ID:

NCBI: 6553
MIM: 600477
HGNC: 11078
Ensembl: ENSG00000135740

Variants:

dbSNP: 6553
ClinVar: 6553
TCGA: ENSG00000135740
COSMIC: SLC9A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135740ENST00000299798Q14940
ENSG00000135740ENST00000564812H3BNY2
ENSG00000135740ENST00000566345J3KSE2
ENSG00000135740ENST00000566626J3KSB3
ENSG00000135740ENST00000567247J3QRV1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27745ELF2GenePathwayassociated

References

Pubmed IDYearTitleCitations
315953892019NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells.10
315953892019NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells.10
249360552014Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.9
249360552014Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.9
212968762011CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.7
215510742011Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5.27
212968762011CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.7
215510742011Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5.27
192760892009Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.16
192760892009Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.16
169203322007RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.15
169203322007RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.15
156993392005beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.20
156993392005beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.20
122050892002Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.19

Citation

Dessen P

SLC9A5 (solute carrier family 9 member A5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73496/css/welcome