TRIM6 (tripartite motif containing 6)

2014-11-01  

Identity

HGNC
TRIM6
LOCATION
11p15.4
LOCUSID
117854
ALIAS
RNF89
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 117854
MIM: 607564
HGNC: 16277
Ensembl: ENSG00000121236

Variants:

dbSNP: 117854
ClinVar: 117854
TCGA: ENSG00000121236
COSMIC: TRIM6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121236ENST00000278302Q9C030
ENSG00000121236ENST00000380097Q9C030
ENSG00000121236ENST00000380107E9PFM0
ENSG00000121236ENST00000424369C9JNQ0
ENSG00000121236ENST00000445329Q9C030
ENSG00000121236ENST00000506134Q9C030
ENSG00000121236ENST00000507320Q9C030
ENSG00000121236ENST00000515022Q9C030
ENSG00000121236ENST00000621176E9PFM0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
384208292024TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein.0
385153772024TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.1
384208292024TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein.0
385153772024TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.1
366547812023TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.11
372365512023TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.2
377596982023TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas.2
388130072023Tripartite motif protein 6 promotes hepatocellular carcinoma progression via multiple pathways.0
366547812023TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.11
372365512023TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.2
377596982023TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas.2
388130072023Tripartite motif protein 6 promotes hepatocellular carcinoma progression via multiple pathways.0
337288632021Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1.9
337288632021Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1.9
316949462020VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection.20

Citation

Dessen P

TRIM6 (tripartite motif containing 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75172/case-report-explorer/hgnc