TRIM69 (tripartite motif containing 69)

2014-11-01  

Identity

HGNC
TRIM69
LOCATION
15q21.1
LOCUSID
140691
ALIAS
HSD-34,HSD34,RNF36,Trif
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140691
MIM: 616017
HGNC: 17857
Ensembl: ENSG00000185880

Variants:

dbSNP: 140691
ClinVar: 140691
TCGA: ENSG00000185880
COSMIC: TRIM69

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185880ENST00000329464Q86WT6
ENSG00000185880ENST00000338264Q86WT6
ENSG00000185880ENST00000558329Q86WT6
ENSG00000185880ENST00000559390Q86WT6
ENSG00000185880ENST00000560442Q86WT6
ENSG00000185880ENST00000561043H0YL66
ENSG00000185880ENST00000561170H0YKB8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377394112023The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.0
378640332023TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD.2
377394112023The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.0
378640332023TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD.2
353977012022Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.4
362519892022Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.4
364235202022HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.22
353977012022Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.4
362519892022Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.4
364235202022HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.22
308446442019TRIM69 inhibits cataractogenesis by negatively regulating p53.22
313755752019TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.23
308446442019TRIM69 inhibits cataractogenesis by negatively regulating p53.22
313755752019TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.23
301422142018Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3.43

Citation

Dessen P

TRIM69 (tripartite motif containing 69)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75180/gene-fusions/haematological-explorer/