TSEN15 (tRNA splicing endonuclease subunit 15)

2014-11-01 Affiliation

Identity

HGNC

TSEN15

LOCATION

1q25.3

LOCUSID

116461

ALIAS

C1orf19,PCH2F,sen15

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 116461
MIM: 608756
HGNC: 16791
Ensembl: ENSG00000198860

Variants:

dbSNP: 116461
ClinVar: 116461
TCGA: ENSG00000198860
COSMIC: TSEN15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198860	ENST00000361641	A0A2U3TZM3
ENSG00000198860	ENST00000423085	Q8WW01
ENSG00000198860	ENST00000462677	H0YCV5
ENSG00000198860	ENST00000485209	F2Z3M0
ENSG00000198860	ENST00000533373	E9PPN1
ENSG00000198860	ENST00000643231	A0A2R8YDU8
ENSG00000198860	ENST00000643702	A0A2R8Y5Q6
ENSG00000198860	ENST00000643916	A0A2R8Y5L0
ENSG00000198860	ENST00000644145	A0A2R8YEM0
ENSG00000198860	ENST00000644479	A0A2R8Y7T8
ENSG00000198860	ENST00000644592	A0A2R8YG40
ENSG00000198860	ENST00000644815	A0A2R8Y5W5
ENSG00000198860	ENST00000645668	Q8WW01
ENSG00000198860	ENST00000645668	B1ALV0
ENSG00000198860	ENST00000645963	A0A2R8Y6B3
ENSG00000198860	ENST00000646297	A0A2R8YHG0
ENSG00000198860	ENST00000647437	A0A2R8Y6A4
ENSG00000198860	ENST00000647465	A0A2R8Y6M5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the nucleus	REACTOME	R-HSA-6784531

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34584079	2021	Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.	13
34584079	2021	Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.	13
27392077	2016	Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly.	27
27392077	2016	Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly.	27
24944287	2014	Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study.	18
24944287	2014	Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study.	18
20546612	2010	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	28
20546612	2010	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	28

Citation

Dessen P

TSEN15 (tRNA splicing endonuclease subunit 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75221/favicon/meetings/