UPF2 (UPF2 regulator of nonsense mediated mRNA decay)

2014-11-01  

Identity

HGNC
UPF2
LOCATION
10p14
LOCUSID
26019
ALIAS
HUPF2,RENT2,smg-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26019
MIM: 605529
HGNC: 17854
Ensembl: ENSG00000151461

Variants:

dbSNP: 26019
ClinVar: 26019
TCGA: ENSG00000151461
COSMIC: UPF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151461ENST00000356352Q9HAU5
ENSG00000151461ENST00000357604Q9HAU5
ENSG00000151461ENST00000397053Q9HAU5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

References

Pubmed IDYearTitleCitations
380562472024An alternative spliced UPF2 transcript in pancreatic inflammatory myofibroblastic tumors.0
387098912024UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.0
380562472024An alternative spliced UPF2 transcript in pancreatic inflammatory myofibroblastic tumors.0
387098912024UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.0
364561822023Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.6
364561822023Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.6
356409742022Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.6
356409742022Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.6
315858092019Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.32
316999822019Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP.19
315858092019Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.32
316999822019Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP.19
267405842016Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.32
267405842016Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.32
241739622014Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells.4

Citation

Dessen P

UPF2 (UPF2 regulator of nonsense mediated mRNA decay)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75496/case-report-explorer/gene-explorer/gene-fusions-explorer/