VPS37C (VPS37C subunit of ESCRT-I)

2014-11-01  

Identity

HGNC
VPS37C
LOCATION
11q12.2
LOCUSID
55048
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55048
MIM: 610038
HGNC: 26097
Ensembl: ENSG00000167987

Variants:

dbSNP: 55048
ClinVar: 55048
TCGA: ENSG00000167987
COSMIC: VPS37C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167987ENST00000301765A5D8V6
ENSG00000167987ENST00000538036F5H4Q5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-I complexKEGGhsa_M00409
ESCRT-I complexKEGGM00409
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Synthesis And Processing Of GAG, GAGPOL PolyproteinsREACTOMER-HSA-174495
Membrane binding and targetting of GAG proteinsREACTOMER-HSA-174490
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373077062023VPS37C facilitates erythroid differentiation by promoting EKLF stability.0
373077062023VPS37C facilitates erythroid differentiation by promoting EKLF stability.0
239247352013VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.13
239247352013VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.13
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.9
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.9
155095642005Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.43
155095642005Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.43

Citation

Dessen P

VPS37C (VPS37C subunit of ESCRT-I)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75635/gene-fusions/cancer-prone-explorer/