ZNRF1 (zinc and ring finger 1)

2014-11-01 Affiliation

Identity

HGNC

ZNRF1

LOCATION

16q23.1

LOCUSID

84937

ALIAS

NIN283

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84937
MIM: 612060
HGNC: 18452
Ensembl: ENSG00000186187

Variants:

dbSNP: 84937
ClinVar: 84937
TCGA: ENSG00000186187
COSMIC: ZNRF1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186187	ENST00000320619	Q8ND25
ENSG00000186187	ENST00000335325	Q8ND25
ENSG00000186187	ENST00000566250	H3BRB6
ENSG00000186187	ENST00000567962	Q8ND25
ENSG00000186187	ENST00000568351	H3BUF0
ENSG00000186187	ENST00000568511	J3KTB9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36966254	2023	LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.	1
36966254	2023	LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.	1
29626159	2018	Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.	6
29626159	2018	Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.	6
25819896	2015	Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.	18
25819896	2015	Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.	18
22797923	2012	ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.	11
22797923	2012	ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.	11
19844255	2010	Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.	10
19844255	2010	Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.	10
19737534	2009	ZNRF1 interacts with tubulin and regulates cell morphogenesis.	9
19737534	2009	ZNRF1 interacts with tubulin and regulates cell morphogenesis.	9
14561866	2003	ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.	25
14561866	2003	ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.	25

Citation

Dessen P

ZNRF1 (zinc and ring finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/76470/css/gene-explorer/