ZNRF1 (zinc and ring finger 1)

2014-11-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
NIN283
FUSION GENES

Other Information

Locus ID:

NCBI: 84937
MIM: 612060
HGNC: 18452
Ensembl: ENSG00000186187

Variants:

dbSNP: 84937
ClinVar: 84937
TCGA: ENSG00000186187
COSMIC: ZNRF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186187ENST00000320619Q8ND25
ENSG00000186187ENST00000335325Q8ND25
ENSG00000186187ENST00000566250H3BRB6
ENSG00000186187ENST00000567962Q8ND25
ENSG00000186187ENST00000568351H3BUF0
ENSG00000186187ENST00000568511J3KTB9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369662542023LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.1
369662542023LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway.1
296261592018Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.6
296261592018Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.6
258198962015Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.18
258198962015Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.18
227979232012ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.11
227979232012ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.11
198442552010Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.10
198442552010Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.10
197375342009ZNRF1 interacts with tubulin and regulates cell morphogenesis.9
197375342009ZNRF1 interacts with tubulin and regulates cell morphogenesis.9
145618662003ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.25
145618662003ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.25

Citation

Dessen P

ZNRF1 (zinc and ring finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/76470/gene-fusions-explorer/haematological-explorer/