AKAP10 (A-kinase anchoring protein 10)

2003-05-01  

Identity

HGNC
AKAP10
LOCATION
17p11.2
LOCUSID
11216
ALIAS
AKAP-10,D-AKAP-2,D-AKAP2,PRKA10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11216
MIM: 604694
HGNC: 368
Ensembl: ENSG00000108599

Variants:

dbSNP: 11216
ClinVar: 11216
TCGA: ENSG00000108599
COSMIC: AKAP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108599ENST00000225737O43572
ENSG00000108599ENST00000225737A0A0S2Z4Z7
ENSG00000108599ENST00000395536E7EMD6
ENSG00000108599ENST00000460046J3QRM7
ENSG00000108599ENST00000571858I3NI04
ENSG00000108599ENST00000572341I3L479
ENSG00000108599ENST00000576896I3L177
ENSG00000108599ENST00000578898K7EM25
ENSG00000108599ENST00000582611J3QR74
ENSG00000108599ENST00000583951J3QL61

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
285539272017Erythropoietin signaling regulates heme biosynthesis.27
285539272017Erythropoietin signaling regulates heme biosynthesis.27
252133152015PKA RIα/A-kinase anchoring proteins 10 signaling pathway and the prognosis of colorectal cancer.4
253484852015D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold.4
261104992015Genetic association of AKAP10 gene polymorphism with reduced risk of preterm birth.0
252133152015PKA RIα/A-kinase anchoring proteins 10 signaling pathway and the prognosis of colorectal cancer.4
253484852015D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold.4
261104992015Genetic association of AKAP10 gene polymorphism with reduced risk of preterm birth.0
228173282013Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns.1
230951892013Polymorphism 1936A > G in the AKAP10 gene (encoding A-kinase-anchoring protein 10) is associated with higher cholesterol cord blood concentration in Polish full-term newsborns.1
234683632013A-kinase anchoring proteins 10 expression in relation to 2073A/G polymorphism and tumor progression in patients with colorectal cancer.4
228173282013Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns.1
230951892013Polymorphism 1936A > G in the AKAP10 gene (encoding A-kinase-anchoring protein 10) is associated with higher cholesterol cord blood concentration in Polish full-term newsborns.1
234683632013A-kinase anchoring proteins 10 expression in relation to 2073A/G polymorphism and tumor progression in patients with colorectal cancer.4
217014452012Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10.3

Citation

Dessen P

AKAP10 (A-kinase anchoring protein 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/77/haematological-explorer/case-report-explorer/favicon/manifest.json