BID (BH3 interacting domain death agonist)

2003-11-01 Affiliation

Identity

HGNC

BID

LOCATION

22q11.21

LOCUSID

637

ALIAS

FP497

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 637
MIM: 601997
HGNC: 1050
Ensembl: ENSG00000015475

Variants:

dbSNP: 637
ClinVar: 637
TCGA: ENSG00000015475
COSMIC: BID

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000015475	ENST00000317361	P55957
ENSG00000015475	ENST00000342111	P55957
ENSG00000015475	ENST00000399765	P55957
ENSG00000015475	ENST00000399765	B2ZP79
ENSG00000015475	ENST00000399767	P55957
ENSG00000015475	ENST00000399767	B2ZP79
ENSG00000015475	ENST00000399774	P55957
ENSG00000015475	ENST00000399774	A8ASI8
ENSG00000015475	ENST00000551952	P55957
ENSG00000015475	ENST00000551952	A8ASI8
ENSG00000015475	ENST00000611040	P55957
ENSG00000015475	ENST00000611040	B2ZP79
ENSG00000015475	ENST00000614949	P55957
ENSG00000015475	ENST00000614949	B2ZP79
ENSG00000015475	ENST00000615414	P55957
ENSG00000015475	ENST00000615414	B2ZP79
ENSG00000015475	ENST00000617586	B2ZP78
ENSG00000015475	ENST00000622694	P55957
ENSG00000015475	ENST00000622694	A8ASI8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
Apoptosis	KEGG	ko04210
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
p53 signaling pathway	KEGG	hsa04115
Apoptosis	KEGG	hsa04210
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Pathways in cancer	KEGG	hsa05200
Viral myocarditis	KEGG	hsa05416
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Intrinsic Pathway for Apoptosis	REACTOME	R-HSA-109606
Activation, myristolyation of BID and translocation to mitochondria	REACTOME	R-HSA-75108
Activation of BH3-only proteins	REACTOME	R-HSA-114452
Activation of BAD and translocation to mitochondria	REACTOME	R-HSA-111447
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	REACTOME	R-HSA-111453
Activation, translocation and oligomerization of BAX	REACTOME	R-HSA-114294
Activation and oligomerization of BAK protein	REACTOME	R-HSA-111452
TP53 Regulates Transcription of Cell Death Genes	REACTOME	R-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	REACTOME	R-HSA-6803204
Apoptosis - multiple species	KEGG	ko04215
Apoptosis - multiple species	KEGG	hsa04215
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37443114	2023	BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.	1
37443114	2023	BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.	1
34931711	2022	BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.	46
34931711	2022	BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.	46
34389447	2021	Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.	3
34389447	2021	Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.	3
30652348	2019	Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.	3
31767857	2019	BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.	11
30652348	2019	Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.	3
31767857	2019	BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.	11
29440708	2018	Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.	12
29969781	2018	MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.	9
30281024	2018	Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.	16
29440708	2018	Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.	12
29969781	2018	MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.	9

Citation

Dessen P

BID (BH3 interacting domain death agonist)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/792/css/lib/favicon/tumors-explorer/welcome