BMP2 (bone morphogenetic protein 2)

2003-12-01  

Identity

HGNC
BMP2
LOCATION
20p12.3
LOCUSID
650
ALIAS
BDA2,BMP2A,SSFSC,SSFSC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 650
MIM: 112261
HGNC: 1069
Ensembl: ENSG00000125845

Variants:

dbSNP: 650
ClinVar: 650
TCGA: ENSG00000125845
COSMIC: BMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125845ENST00000378827P12643
ENSG00000125845ENST00000378827C8C060

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Basal cell carcinomaKEGGko05217
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

References

Pubmed IDYearTitleCitations
381951942024Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.1
382670602024MicroRNA 98-5p Overexpression Contributes to Delayed Fracture Healing via Targeting BMP-2.0
384722722024BMP2 rs1005464 is associated with mandibular condyle size variation.0
385104912024miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.0
386094242024Whole genome sequencing identifies associations for nonsyndromic sagittal craniosynostosis with the intergenic region of BMP2 and noncoding RNA gene LINC01428.0
386100012024RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.0
381951942024Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.1
382670602024MicroRNA 98-5p Overexpression Contributes to Delayed Fracture Healing via Targeting BMP-2.0
384722722024BMP2 rs1005464 is associated with mandibular condyle size variation.0
385104912024miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.0
386094242024Whole genome sequencing identifies associations for nonsyndromic sagittal craniosynostosis with the intergenic region of BMP2 and noncoding RNA gene LINC01428.0
386100012024RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.0
365808862023PI3K-Akt signaling regulates BMP2-induced osteogenic differentiation of mesenchymal stem cells (MSCs): A transcriptomic landscape analysis.3
366421812023Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition.0
368832702023Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway.0

Citation

Dessen P

BMP2 (bone morphogenetic protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/809/case-report-explorer/css/teaching-explorer/