CCL11 (C-C motif chemokine ligand 11)

2003-05-01  

Identity

HGNC
CCL11
LOCATION
17q12
LOCUSID
6356
ALIAS
SCYA11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6356
MIM: 601156
HGNC: 10610
Ensembl: ENSG00000172156

Variants:

dbSNP: 6356
ClinVar: 6356
TCGA: ENSG00000172156
COSMIC: CCL11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172156ENST00000305869P51671
ENSG00000172156ENST00000305869Q6I9T4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
AsthmaKEGGko05310
Cytokine-cytokine receptor interactionKEGGhsa04060
AsthmaKEGGhsa05310
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166123307insomniaDiseaseVariantAnnotationassociatedPD29222992
PA445043Opioid-Related DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29222992
PA450401methadoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD29222992

References

Pubmed IDYearTitleCitations
381959332024Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.0
383059202024Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling.0
383944972024Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.1
381959332024Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.0
383059202024Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling.0
383944972024Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.1
365768862023Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.4
378600002023Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways.1
365768862023Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.4
378600002023Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways.1
345711762022Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification.4
352540152022Eotaxin-1 Levels in Patients with Myocardial Infarction.4
356909922022Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications.19
345711762022Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification.4
352540152022Eotaxin-1 Levels in Patients with Myocardial Infarction.4

Citation

Dessen P

CCL11 (C-C motif chemokine ligand 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/939/gene-fusions/humanGenome