CCND3 (cyclin D3)

2003-02-01 Affiliation

Identity

HGNC

CCND3

LOCATION

6p21.1

LOCUSID

896

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 896
MIM: 123834
HGNC: 1585
Ensembl: ENSG00000112576

Variants:

dbSNP: 896
ClinVar: 896
TCGA: ENSG00000112576
COSMIC: CCND3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112576	ENST00000372987	Q5T8J1
ENSG00000112576	ENST00000372988	P30281
ENSG00000112576	ENST00000372991	P30281
ENSG00000112576	ENST00000414200	P30281
ENSG00000112576	ENST00000415497	P30281
ENSG00000112576	ENST00000502771	D6RDL3
ENSG00000112576	ENST00000505064	D6RIX2
ENSG00000112576	ENST00000508143	A0A1D5RMS0
ENSG00000112576	ENST00000510503	D6RI00
ENSG00000112576	ENST00000511642	P30281
ENSG00000112576	ENST00000512426	H0Y8M4
ENSG00000112576	ENST00000514588	D6RDF8
ENSG00000112576	ENST00000616010	P30281

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
p53 signaling pathway	KEGG	ko04115
Wnt signaling pathway	KEGG	ko04310
Focal adhesion	KEGG	ko04510
Jak-STAT signaling pathway	KEGG	ko04630
Cell cycle	KEGG	hsa04110
p53 signaling pathway	KEGG	hsa04115
Wnt signaling pathway	KEGG	hsa04310
Focal adhesion	KEGG	hsa04510
Jak-STAT signaling pathway	KEGG	hsa04630
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Cell cycle - G1/S transition	KEGG	hsa_M00692
Cell cycle - G1/S transition	KEGG	M00692
Signal Transduction	REACTOME	R-HSA-162582
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1 Phase	REACTOME	R-HSA-69236
Cyclin D associated events in G1	REACTOME	R-HSA-69231
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36965165	2023	Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.	1
36965165	2023	Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.	1
36161661	2022	Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread.	5
36161661	2022	Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread.	5
34056735	2021	CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.	9
34103301	2021	Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.	8
34406791	2021	Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.	2
34056735	2021	CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.	9
34103301	2021	Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.	8
34406791	2021	Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.	2
30538135	2019	CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.	42
30911281	2019	Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.	3
30950241	2019	Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis.	29
30538135	2019	CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.	42
30911281	2019	Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.	3

Citation

Dessen P

CCND3 (cyclin D3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/955/css/gene-fusions-explorer/tumors-explorer/