t(12;13)(p12;q12-14) ETV6/CDX2

2000-04-01   Nick CP Cross 

1.Wessex Regional Genetics Laboratory Salisbury District Hospital Salisbury, SP2 8BJ, UK

Clinics and Pathology

Disease

chronic myelogenous leukemia (CML) in transformation, myelodysplastic syndrome (MDS), acute non lymphocytic leukemai (AML), B and T- acute lymphocytic leukemias (ALL)

Genes Involved and Proteins

Gene name
ETV6 (ets variant 6)
Location
12p13.2
Gene name
CDX2 (caudal-related homeobox 2)
Location
13q12.2

Highly cited references

Pubmed IDYearTitleCitations
147186722004Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.34
99208521999Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12).20

Bibliography

Pubmed IDLast YearTitleAuthors

Summary

Fusion gene

ETV6/CDX2 ETV6 (12p13.2) CDX2 (13q12.2) M t(12;13)(p13;q12)|ETV6/CDX2 ETV6 (12p13.2) CDX2 (13q12.2) TIC

Citation

Nick CP Cross

t(12;13)(p12;q12-14) ETV6/CDX2

Atlas Genet Cytogenet Oncol Haematol. 2000-04-01

Online version: http://atlasgeneticsoncology.org/haematological/1204/js/template.js