t(1;8)(p22-p32;q22-q23)

2008-02-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML); non-Hodgkin lymphoma (NHL)

Note

The disease is likely to be heterogeneous, with different phenotypes (AML and NHL) for a given breakpoint (1p31 and 8q22), and possibly similar or different breakpoints in different AML cases.

Epidemiology

3 cases of AML: two of which were M2 cases (ages and sex were: 84 years/F; 40 years/ M; ?/?); the NHL case was 71 year-old male patient with a small cleaved cell follicular lymphoma

Genes Involved and Proteins

Note
Genes involved are unknown.

Article Bibliography

Pubmed IDLast YearTitleAuthors
68506081983Nonrandom chromosome abnormalities in lymphoma.Bloomfield CD et al
89081651996Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis.Calabrese G et al
111653152001Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.Kerndrup GB et al
23539671990Acute megakaryocytic leukemia.Moertel CL et al
117469882002Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.Van Limbergen H et al

Citation

Jean-Loup Huret

t(1;8)(p22-p32;q22-q23)

Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1207/gene-explorer/teaching-explorer/