t(1;14)(q21;q32) FCGR2B/IGH

2005-02-01   Jacques Boyer  

1.Laboratoire d hématologie, CH du MANS, France

Clinics and Pathology

Disease

Follicular lymphoma in one CD10+ case, but without a t(14;18)(q32;q21), bcl2 negative, and with a t(1;14)(q21;q32); follicular lymphoma with FCGR2B rearrangement and dup(1)(q21q25)in another case .

Epidemiology

These two cases with FCGR2B rearrangement were found among a panel of 76 non Hodgkins lymphomas.

Prognosis

May be associated with tumor progression.

Genes Involved and Proteins

Gene name
FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
Location
1q23.3
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33

Result of the Chromosomal Anomaly

Description

The translocation juxtapose the 5 switch region og IGHG2 to a region upstream of FCGR2B in the der(1) chromosome.FCGR2B is deregulated by this translocation and FCGR2B b2 mRNA isoform is overexpressed.

Note

No fusion protein.

Oncogenesis

It is possible that alteration in the b2/b1 mRNA isoforms ratio in B-cells may promote B cell survival. This anomaly is bcl2 deregulation-independant because FCGR2B has been shown to be a tumor-enhancing factor in non lymphoid cells in murine in vivo and in vitro models. Deregulation of FCGR2B expression can be considered as a second event which may impart additional growth advantage to the bcl2 deregulated B-cells.

Article Bibliography

Pubmed IDLast YearTitleAuthors
106184142000The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma.Callanan MB et al
117536462001Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas.Chen W et al
117015422000Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma.Macintyre E et al

Citation

Jacques Boyer

t(1;14)(q21;q32) FCGR2B/IGH

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1341/teaching-explorer/favicon/js/web-card-haematological.js