t(7;14)(q21;q13)

2008-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myeloproliferative syndrome (MPD) and acute myeloid leukaemia (AML)

Phenotype stem cell origin

One case was a M2-AML, another case was a MPD associated with an AML, the third case was an AML not otherwise specified.

Epidemiology

Only three cases available; two male and one female patients aged 62, 63, and 71 yrs.

Cytogenetics

Cytogenetics morphological

The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.

Additional anomalies

The three cases present with very similar cytogenetic profiles: major karyotypic anomalies were present in 3 out of 3 cases; -5/del(5q) was found in the three cases, and +8 and -14 were found in two cases each.

Genes Involved and Proteins

Note
Genes involved are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors

Citation

Jean-Loup Huret

t(7;14)(q21;q13)

Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1484/js/template.js